Preclinical Metabolism Studies

BioLegacy’s areas of expertise include:

Diabetes

Obesity

Diabetes

Preclinical evaluation of novel anti-diabetic agents requires translatable models that accurately recapitulate the distinct pathophysiologies of hyperglycemia and insulin resistance. BioLegacy utilizes a comprehensive, multi-species platform of well-characterized Type 1 and Type 2 diabetes models. Integrating these gold-standard genetic and induced models with pivotal functional tests of glucose homeostasis, we deliver clear, quantitative data on glycemic control and insulin sensitivity essential for advancing your diabetes therapeutic.

  • Type 1 & 2 Models (Mouse, Rat, Minipig): Multi-species assessments in both autoimmune-driven (T1D) and metabolic (T2D) disease contexts.
  • Diet-Induced Type 2 Diabetes: High-fat diet with streptozotocin induces a clinically relevant state of obesity, insulin resistance, and hyperglycemia.
  • Genetic Models (Mouse, Rat): Spontaneous genetic models (e.g., Zucker rats) that recapitulate the pathophysiology of metabolic syndrome.
  • db/db Mouse Models: The gold-standard monogenic model of severe Type 2 diabetes, driven by leptin receptor deficiency.
  • Oral Glucose Tolerance Test (OGTT): A critical functional assay to assess a therapeutic's impact on glucose disposal following an oral glucose challenge.
  • Insulin Tolerance Tests (IP & IV): A key in vivo test to quantitatively measure a compound's effect on peripheral insulin sensitivity.
  • Diabetic Models in Pigs: A highly translatable large animal model for studying diabetic complications and testing medical devices in a diabetic setting.

Obesity

BioLegacy’s evaluation of anti-obesity therapeutics extend beyond simple body weight measurement to nuanced characterizations of their effect on body composition and energy expenditure. We use both diet-induced and genetic models of obesity to provide these holistic assessments. Integrating gold-standard in vivo systems with precise, quantitative bioanalytical readouts, we deliver a clear, mechanistic profile of your compound’s ability to reduce adiposity, preserve lean mass, and favorably alter metabolic parameters.

  • Diet-Induced Obesity: The gold-standard translational model using high-fat diets to induce a polygenic obesity phenotype that closely mimics the human condition.
  • Genetic Models of Obesity (Mouse & Rat): Expertise in leveraging monogenic models (e.g., ob/ob, db/db, Zucker rats) with severe, early-onset obesity for robust mechanistic and efficacy studies.
Don’t see a model you need? Our portfolio of validated models expands all the time. Ask us - we might have it!
Tip the scales in favor of your IND submission.
  • Study design support
  • Small & large animal studies
  • IND-enabling GLP studies
  • Optional SEND datasets
  • Rapid study initiation - usually in under 2 weeks
BioLegacy delivers the data you need. Contact us!