Mini-Pigs / Pigs

The porcine model’s profound anatomical and physiological parallels to humans make it an excellent large animal for studies including surgical research, medical device evaluation, and dermatology. BioLegacy utilizes both domestic swine and minipigs for pivotal studies where human-like organ size, skin structure, and cardiovascular systems are critical for generating predictive data. Our world-class surgical expertise, state-of-the-art facilities, and regulatory acumen ensure generation of robust safety, efficacy, and biocompatibility data required to de-risk your program and support your IDE or IND submission.

  • Gold-Standard for Medical Devices: Evaluate cardiovascular (e.g., stents, valves), orthopedic, and surgical devices with pigs’ profound anatomical similarity.
  • Translational Surgical Research: State-of-the-art surgical suites and world-renowned veterinary surgeons for developing and validating complex surgical and interventional procedures.
  • Dermatology & Transdermal Delivery: The most well-established and predictive model for dermal safety, absorption, and wound healing studies.
  • Cardiovascular & Metabolic Disease: Well-established models for research in atherosclerosis, myocardial infarction, and other cardiovascular and cardiometabolic conditions.
  • Minipig Toxicology: Advantages over dogs in GLP tox studies where gastrointestinal physiology and certain aspects of metabolism are of particular concern.
  • Advanced Imaging & Functional Support: Access to large-animal imaging and hemodynamic monitoring to support complex studies.
  • AAALAC-Accredited Care for the highest standards of animal welfare and data quality.
Medical Device & Surgical Studies

BioLegacy provides a definitive testing environment by leveraging the porcine model as a critical, near-human surrogate for the most complex medical device and surgical studies. Our expert surgeons utilize the porcine platform to assess not just the implant, but the entire procedural workflow, providing critical insights into usability, performance, and the host’s physiological response. This holistic focus ensures your medical innovation is thoroughly de-risked before human application.

  • Anatomical & Physiological Fidelity: Organ size, tissue, and physiological responses closely mimic that of humans.
  • Complex Procedural & Surgical Validation: Expertise in surgical workflows for novel surgical procedures and human-scale implantable medical devices.
  • Advanced Intraoperative & Post-Op Monitoring: State-of-the-art surgical suites with integrated imaging and hemodynamic monitoring to capture critical performance data.
  • Pivotal Data for IDE Submissions: A proven track record of generating robust safety and performance data packages for successful regulatory filings.
A Gold Standard for Dermatology

The porcine model is the premier translational platform for dermatology, as its epidermal thickness, dermal-epidermal junction structure, hair follicle density, and collagen content most closely recapitulate that of humans. BioLegacy leverages the porcine model to provide sponsors with maximum predictability in studies of dermatological conditions or which involve topical or transdermal therapeutics. We provide definitive assessments of dermal absorption, local tolerance, and efficacy for your novel creams, ointments, and transdermal systems, providing the critical data needed to advance your program.

  • Gold-Standard Human Skin Surrogate for dermal and transdermal research.
  • Comprehensive Dermal Safety & Irritation Studies
  • Wound Healing & Scar Formation: Expertise in excisional and incisional models to evaluate regenerative therapeutics.
  • PK of Topically Applied Compounds: Quantifying drug absorption and systemic exposure after dermal application.
  • Transdermal System (Patch) Evaluation: Specialized studies to assess the adhesion, delivery, and performance of transdermal patches.
Cardiovascular Studies in Pigs

Generating clinically relevant data for a cardiovascular therapeutic requires a model which closely mimics human cardiovascular anatomy and function. The porcine model’s profound functional and hemodynamic parallels provide a highly predictive platform for your most complex cardiovascular studies. BioLegacy’s expertise in modeling diseases like myocardial infarction and atherosclerosis allows for a definitive assessment of your compound or device’s impact on cardiac performance, vascular response, and electrophysiology.

  • Human-like Cardiac & Vascular Physiology: Heart size, coronary anatomy, and hemodynamic responses closely mirror humans.
  • Interventional Cardiology Expertise: Capabilities for catheter-based procedures, including stent deployment and intravascular imaging.
  • Myocardial Infarction & Ischemia Models to evaluate cardioprotective and regenerative therapies.
  • Advanced Hemodynamic & Functional Monitoring: In-depth assessment of cardiac function using pressure-volume (PV) loop analysis and echocardiography.
  • Atherosclerosis & Restenosis Studies: Extensively validated diet-induced and injury models to test novel cardiovascular therapeutics.
Toxicology Studies in Minipigs

When specific metabolic pathways, dermal absorption, or gastrointestinal physiology are critical to your compound’s safety profile, the minipig offers a scientifically superior non-rodent model. BioLegacy leverages the minipig for GLP-compliant toxicology studies where its human-like characteristics provide a more predictive and translatable dataset than the canine model. Our expertise in this increasingly important species ensures a robust and scientifically justified IND-enabling data package for your specialized therapeutic.

  • Superior Human-like Dermal Model: The gold standard non-rodent species for toxicology of topical and transdermal therapeutics.
  • Predictive GI Tract Physiology: An ideal model for orally administered drugs with complex absorption or GI-related targets.
  • Closer Metabolic Parallels for Certain Drug Classes: A more translational metabolic profile for specific enzyme pathways (e.g., certain CYPs).
  • Accepted Non-Rodent Species: A fully validated and accepted alternative to canines for GLP toxicology.
Get to Clinic Sooner

De-risk your cardiovascular program and advance to Phase I with confidence!

  • Extensive porcine experience
  • World-class surgical capabilities
  • GLP-compliant, IND-enabling studies
  • Hundreds of animal models
  • AAALAC-accredited facilities

Contact us today and let’s get started.