Ovine Studies

A Crucial Model for Medical Devices & Reproductive Safety

The ovine model’s large size and human-like reproductive, cardiovascular, bone, and pulmonary physiology make it an excellent platform for translational research involving medical devices and complex surgical procedures. At BioLegacy, we utilize sheep for long-term cardiovascular and maternal-fetal medicine studies where their physiological parallels are critical. Our best-in-class surgical expertise and state-of-the-art facilities ensure the generation of the definitive safety, efficacy, and performance data required to de-risk your program and support your IDE or IND submissions.

  • Orthopedics & Bone Regeneration: Bone mineral density and remodeling processes that parallel humans make sheep an excellent model for evaluating orthopedic implants, bone grafts, and tissue engineering.
  • Cardiovascular Device Testing: BioLegacy has deep expertise in surgical implantation and long-term evaluation of cardiovascular devices such as heart valves, stents, and ventricular assist devices (VADs).
  • Maternal-Fetal & Reproductive Medicine: Sheep are a well-established translational model for studying placental function, fetal development, and the safety of therapeutics during pregnancy.
  • Advanced Surgical & Interventional Models: State-of-the-art surgical suites and technical expertise for developing and performing complex surgeries.
  • Translational Biocompatibility Assessment: Long-term assessment of the host response to implantable biomaterials and devices.
Cardiovascular & Implantable Medical Device Research

The human-like size and anatomy of the ovine heart and vasculature make it the ideal platform for rigorous, long-term evaluation of cardiovascular devices and complex surgical procedures. Our world-class veterinary surgeons leverage this model in state-of-the-art surgical suites to perform intricate implantations and interventions. This capability, combined with advanced intraoperative and post-operative monitoring, provides the critical safety and performance data that is essential for de-risking your innovative device before human use.

  • Structural Heart Device Testing: Surgical implantation and evaluation of heart valves, annuloplasty rings, and septal occluders.
  • Vascular Grafts & Stents: Long-term assessment of graft patency, endothelialization, and neointimal hyperplasia.
  • Ventricular Assist Device (VAD) Implantation: A robust model for long-term studies of cardiac support devices.
  • Advanced Hemodynamic Monitoring: Expertise in pressure-volume (PV) loop analysis and continuous telemetry.
Maternal-Fetal Medicine & Reproductive Safety

For questions of reproductive safety and fetal development, the pregnant ewe is an extraordinary translational model. BioLegacy provides a specialized platform for maternal-fetal medicine, leveraging the ovine model’s similar gestational timeline and fetal physiology to humans. Our expertise allows for the safe, long-term assessment of therapeutics and devices on both the mother and the developing fetus.

  • Placental Transfer & Fetal PK: Pharmacokinetic studies to determine fetal exposure to your novel therapeutic.
  • Maternal & Fetal Physiology Monitoring: Long-term studies of cardiovascular and metabolic function.
  • Reproductive & Developmental Safety: When more human-like reproductive physiology is needed, sheep are superior to rabbits for reproductive safety and DART studies.
  • Uterine & Placental Blood Flow Studies: Utilizing advanced techniques to assess the hemodynamic effects of new interventions.
Translational Pulmonary & Airway Disease Models

Modeling the complex architecture and physiological responses of the human lung in small animals poses a significant challenge in preclinical research. The ovine model provides a superior solution, offering remarkable similarities in lung size, airway branching, and cellular composition that are highly translatable to human respiratory medicine. At BioLegacy, we leverage these advantages to create robust models of chronic and acute lung disease that can be leveraged in the most demanding studies. Our ovine models provide an authoritative platform for evaluating inhaled therapeutics, medical devices, and novel ventilation strategies.

  • Inhaled Therapeutic & Device Testing: Expertise in aerosol and particle delivery for PK/PD and efficacy studies of inhaled drugs and devices.
  • Asthma & Airway Hyperresponsiveness: Allergen-induced models to assess bronchoconstriction and inflammation.
  • Chronic Obstructive Pulmonary Disease (COPD): Long-term smoke exposure and porcine pancreatic elastase (PPE)-induced models to study emphysema and chronic bronchitis.
  • Bleomycin-induced Lung Fibrosis: Localized induction for the testing of potential anti-fibrotic drugs by measuring structural and functional changes with same-animal control.
Proven Preclinical Experience

A quarter century of service to pharmaceutical, biologics, and medical device developers.

  • World-renowned veterinary surgeons
  • New, state-of-the-art facilities
  • Hundreds of animal models
  • AAALAC-accreditation
  • Rapid study initiation - usually 2 weeks or less!

See how much we can do for your program. Contact us today!