The rat model is the quintessential system for regulatory-driven toxicology and complex pharmacology, prized for a well-characterized physiology that provides robust, translatable data. BioLegacy leverages this cornerstone model to its fullest potential in pivotal GLP-compliant safety pharmacology, advanced neurobehavioral studies, and surgically induced models. BioLegacy works with all national breeders and can procure immunocompromised animals or genetically modified rats from dedicated partner labs. Our deep expertise delivers the comprehensive toxicokinetic, safety, and efficacy data packages required to de-risk your program and ensure a confident transition to IND.
- ICH-Compliant Safety Pharmacology: Core battery assessments including continuous cardiovascular monitoring via implanted telemetry for precise hemodynamic and ECG analysis.
- Advanced Neurobehavioral & Cognitive Testing: Validated models of psychiatric and neurodegenerative disorders with complex behavioral testing.
- GLP-Compliant Toxicology: Industry-standard, IND-enabling repeat-dose toxicology studies.
- Complex Surgical & Disease Models: Sophisticated models like middle cerebral artery occlusion (MCAO) for stroke research.
- Metabolic & Cardiovascular Disease: Established diet- and chemically-induced models of diabetes, dyslipidemia, and hypertension.
- DART (Developmental & Reproductive Toxicology): A validated rodent species for the full suite of reproductive toxicology studies.
- Full Bioanalytical & Pathology Integration: Seamless in-house support for TK/PK analysis and expert pathological interpretation of study endpoints.
