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Preclinical Musculoskeletal Studies

BioLegacy’s areas of expertise include:

Bone Healing

Bone Healing

A definitive evaluation of an osteogenic or bone-reparative therapeutic requires a multi-modal assessment that integrates structural, functional, and cellular endpoints. BioLegacy’s bone healing platform provides this comprehensive characterization, utilizing a suite of well-established surgical models to create clinically relevant bone defects. Combining advanced ex vivo imaging with functional biomechanical testing and histomorphometry, we deliver a complete, unambiguous data package on your compound or device’s ability to accelerate and enhance the bone regeneration process.

  • Orthotopic & Ectopic Bone Healing (Rat, Rabbit): Expertise in both critical-sized defect (orthotopic) and subcutaneous implantation (ectopic) models for a multi-faceted assessment of osteoinduction and osteointegration.
  • Functional Biomechanical Testing: Determine key functional properties like maximal torque, stiffness, and structural strength.
  • Histomorphometry: Cellular-level data on bone formation rate, osteoblast / osteoclast activity, and implant osseointegration.
Don’t see a model you need? Our portfolio of validated models expands all the time. Ask us - we might have it!
Strong INDs & IDEs start with BioLegacy.
  • Large & small animal studies
  • State-of-the-art, AAALAC-accredited facilities
  • Advanced bioanalytical capabilities
  • “Extra Mile” service & support
  • Rapid study initiation - usually in under 2 weeks
Contact BioLegacy & let’s advance your pipeline!