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Preclinical Nephrology & Urology Studies

BioLegacy’s areas of expertise include:

Kidney Disease

Kidney Disease

A definitive preclinical evaluation of a renoprotective therapeutic requires a model that accurately recapitulates the specific pathophysiology of either acute or chronic kidney injury. BioLegacy provides this critical distinction, offering an extensive platform of well-characterized surgical and toxin-induced nephropathy models. Integrating these robust in vivo systems with pivotal functional and histopathological endpoints, we deliver a clear, quantitative assessment of your compound’s ability to preserve renal function and mitigate tissue fibrosis.

  • General Nephrotoxicity Models: Utilizes agents like cisplatin or gentamicin to assess a compound's potential for drug-induced kidney injury (DIKI) or to test renoprotective agents.
  • 5/6 Nephrectomy: The gold-standard surgical model of chronic kidney disease (CKD), inducing progressive glomerulosclerosis, interstitial fibrosis, and hypertension.
  • Ischemia-Reperfusion (IR) Acute Renal Failure Model: A robust surgical model of acute kidney injury (AKI) that mimics the pathology seen in renal transplantation and ischemic shock.
  • Unilateral Ureteral Obstruction (UUO): A rapid, well-characterized model of interstitial renal fibrosis, ideal for screening anti-fibrotic compounds.
  • Organ Cell Inoculation (Kidney): Subcapsular implantation of renal or tumor cells (e.g., for renal cell carcinoma) to study localized disease or cell therapy engraftment.
Don’t see a model you need? Our portfolio of validated models expands all the time. Ask us - we might have it!
De-risk your pipeline and confidently advance to the clinic.
  • GLP & non-GLP studies
  • Small & large animal studies
  • State-of-the-art, AAALAC-accredited facilities
  • Advanced bioanalytical capabilities
  • Rapid study initiation - usually in under 2 weeks
Contact BioLegacy and get the data you need!